I'm working on a Unicode version of TIPA, with lots of additional glyphs & diacritics. I need to define OT features governing diacritic placement, but for practical purposes it's hard to define all 180 x 180 pairs. I'm looking for ideas which pairs to definitely include (on top of those already present in the Unicode standard in the form of pre-composed characters, such as "a circumflex acute"), and for pairs placed in the same position, e.g. both at the bottom, or both at the top.
I additionally have a problem with long descender glyphs, as used in transcription, with bottom diacritics. The IPA only gives the example of "eng" + "combining ring below". Are there other instances I should provide for? What's the best practice in situations when moving a diacritic from the bottom to the top position would change the meaning of that diacritic, e.g. retracted vs. mid (tone, level), voiced vs. rising (tone, contour)?
Thank you for your help!