As under normal category code régime you cannot obtain control-word-tokens like \2x2 directly by having TeX read and tokenize .tex-input and as correct invocation of \csname..\endcsname in combination with \expandafter sometimes seems cumbersome, I offer a macro \CsNameToCsToken to create, e.g., the control-word-token \2x2 from the character-token-sequence 2x2.
Syntax:
\CsNameToCsToken⟨stuff not in braces⟩{⟨NameOfCs⟩}
→
⟨stuff not in braces⟩\NameOfCs
(⟨stuff not in braces⟩ may be empty.)
(Due to \romannumeral-expansion the result is obtained by triggering two expansion-steps, e.g., by having two "hits" with \expandafter.)
With such a macro you are not bound to specific definition commands:
\CsNameToCsToken{foo} → \foo .
\CsNameToCsToken\newcommand{foo} → \newcommand\foo .
\CsNameToCsToken\DeclareRobustCommand{foo} → \DeclareRobustCommand\foo .
\CsNameToCsToken\global\long\outer\def{foo} → \global\long\outer\def\foo .
\CsNameToCsToken\expandafter{foo}\bar → \expandafter\foo\bar .
\CsNameToCsToken\let{foo}=\bar → \let\foo=\bar .
\CsNameToCsToken\CsNameToCsToken\let{foo}={bar} → \CsNameToCsToken\let\foo={bar} → \let\foo=\bar .
\CsNameToCsToken\string{foo} → \string\foo .
\CsNameToCsToken\meaning{foo} → \meaning\foo .
\CsNameToCsToken\NewDocumentCommand{foo}... → \NewDocumentCommand\foo... .
\makeatletter
%%===============================================================================
%% End \romannumeral-driven expansion safely:
%%===============================================================================
\@ifdefinable\UD@stopromannumeral{\chardef\UD@stopromannumeral=`\^^00}%
%%===============================================================================
%% Obtain control sequence token from name of control sequence token:
%%===============================================================================
%% \CsNameToCsToken<stuff not in braces>{NameOfCs}
%% -> <stuff not in braces>\NameOfCs
%% (<stuff not in braces> may be empty.)
\@ifdefinable\CsNameToCsToken{%
\long\def\CsNameToCsToken#1#{\romannumeral\InnerCsNameToCsToken{#1}}%
}%
\newcommand\InnerCsNameToCsToken[2]{%
\expandafter\UD@exchange\expandafter{\csname#2\endcsname}{\UD@stopromannumeral#1}%
}%
\newcommand\UD@exchange[2]{#2#1}%
\makeatother
\documentclass{article}
\usepackage{amsmath, amssymb}
\CsNameToCsToken\newcommand*{2x2}{2 \times 2}
\begin{document}
Let $A \in \mathbb{K}^{\CsNameToCsToken{2x2}}$, \dots
\end{document}

\NewDocumentCommand{\MAT}{>{\SplitArgument{1}{x}}m}{\makeMAT#1}and\NewDocumentCommand{\makeMAT}{mm}{\mathbb{K}^{#1\IfValueT{#2}{\times#2}}}will allow you to use\MAT{2x2}and\MAT{2}; but also\MAT{m x n}– egreg Dec 18 '21 at 11:04\2x2, you might also want\3x3or\3x4and so on. Do you think this will make your input easier? – egreg Dec 18 '21 at 11:31