Consider the code
\documentclass{book}
\usepackage{imakeidx}
\let\cleardoublepage\clearpage
\makeindex
\usepackage{idxlayout}
\usepackage{lipsum}
\usepackage[none]{hyphenat} % To prevent hyphenation
\begin{document}
\large
\lipsum[13]\index{HEADING@\textbf{\textit{HEADING}}! \lipsum[3]}
\idxlayout{columns=1}
\printindex
\end{document}
which produces the Index:
I have prevented hyphenation in the document by inserting \usepackage[none]{hyphenat} into the preamble; however, I would like to permit hyphenation in the Index.
QUESTION: Is it possible to permit hyphenation in the Index while simultaneously precluding it from occurring in the rest of the document? If so, how may I do this?
Thank you.

\hbadness=1000and hyphenation occurred in the index, as I wanted. Would you tell me what this command does and why it might be needed? Thank you again. – DDS Jan 02 '22 at 03:05\hbadnessis not really needed, it's just helpful to report overfull boxes in the logs. You can read some useful info here: https://tex.stackexchange.com/questions/241343/what-is-the-meaning-of-fussy-sloppy-emergencystretch-tolerance-hbadness/241355 – jak123 Jan 02 '22 at 03:58