If you want to enclose the entire tree in a brace:

you can use \left. and right\}:
$\left.\vcenter{\hbox{
<forest code goes here>
}}\right\}$
On the other hand, if you want to separate parts of the tree with braces it's a bit more complicated. Here is a possibility using. the calligraphy library to draw the braces.

Use name to name the nodes where the splits occur. Then set coordinates at the northeast and southeast corners of the current bounding box. Then draw the brace using the named nodes. Since the north edges of the nodes do not quite reach the couth edge of the previous node, a manual adjustments using [yshift=] may improve the appearance.
Here is the code:
\documentclass{article}
\usepackage{forest}
\usetikzlibrary {decorations.pathreplacing, calligraphy}
\tikzset{mybrace/.style={decorate, decoration={calligraphic brace, amplitude=2mm},ultra thick}, label={0:d}}
\definecolor{folderbg}{RGB}{124,166,198}
\definecolor{folderborder}{RGB}{110,144,169}
\def\Size{4pt}
\tikzset{
folder/.pic={
\filldraw[draw=folderborder,top color=folderbg!50,bottom color=folderbg]
(-1.05\Size,0.2\Size+5pt) rectangle ++(.75\Size,-0.2\Size-5pt);
\filldraw[draw=folderborder,top color=folderbg!50,bottom color=folderbg]
(-1.15\Size,-\Size) rectangle (1.15\Size,\Size);
}
}
\begin{document}
\begin{forest}
for tree={
font=\ttfamily,
grow'=0,
child anchor=west,
parent anchor=south,
anchor=west,
calign=first,
inner xsep=7pt,
edge path={
\noexpand\path [draw, \forestoption{edge}]
(!u.south west) +(7.5pt,0) |- (.child anchor) pic {folder} \forestoption{edge label};
},
% style for your file node
file/.style={edge path={\noexpand\path [draw, \forestoption{edge}]
(!u.south west) +(7.5pt,0) |- (.child anchor) \forestoption{edge label};},
inner xsep=2pt, font=\small\ttfamily
},
before typesetting nodes={
if n=1
{insert before={[,phantom]}}
{}
},
fit=band,
before computing xy={l=15pt},
}
[system, name=system
[config, name= config
]
[lib, name=lib node
[Access, name=access
]
[Plugin, name=plugin
]
[file.txt, file, name=file
]
]
[templates, name=templaes
]
[tests, name=tests
]
]
\coordinate(top) at (current bounding box.north east);
\coordinate(bot) at (current bounding box.south east);
\draw[mybrace] (top)--node[right=2mm]{Explanation 1}(top|-config.south)coordinate(A);
\draw[mybrace] (A)--node[right=2mm]{Explanation 2}([yshift=-1mm]top|-access.south)coordinate(B);
\draw[mybrace] (B)--node[right=2mm]{Explanation 3}([yshift=-1mm]top|-file.south)coordinate(C);
\draw[mybrace] (C)--node[right=2mm]{Explanation 4}(bot);
\end{forest}
\end{document}