Corynoline

Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.[1]

Corynoline
Names
IUPAC name
13-Methylchelidonine
Systematic IUPAC name
(5bR,6S,12bR)-5b,13-Dimethyl-5b,6,7,12b,13,14-hexahydro-2H,10H-[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-h]phenanthridin-6-ol
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.208.689
EC Number
  • 683-177-2
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1
    Key: IQUGPRHKZNCHGC-TYPHKJRUSA-N
  • InChI=1/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1
    Key: IQUGPRHKZNCHGC-TYPHKJRUBF
SMILES
  • O1c2c(OC1)c3c(cc2)[C@@]5([C@H](N(C3)C)c4cc6OCOc6cc4C[C@@H]5O)C
Properties
Chemical formula
 C21H21NO5
Molar mass 367.401 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Kim, DK (2002). "Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase". Archives of Pharmacal Research. 25 (6): 817–9. doi:10.1007/bf02976997. PMID 12510831. S2CID 35891875.


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