I have thought about this question for a very long time. The question will be described as the following.
I have an effective Feynman loop diagram to calculate, which describing B meson decay into 3 particles. There are 4 propagators. After using Feynman parameterization and completing the square and shifting the loop momentum, the denominator looks like $l^2-\Delta$, where $l$ is the loop momentum, $\Delta$ is a function of Feynman parameters and external momenta.
$$ \frac{1}{[k^2-m_4^2][(k+p_1)^2-m_1^2][(k+p_2+p_3)^2-m_2^2][(k+p_3)^2-m_3^2]}=... \\=\int_0^1dx_1dx_2dx_3dx_4\delta(\sum x_i-1)\frac{3!}{[l^2-\Delta]^4} $$
It is easy to handle it when $\Delta > 0$, but I have no idea about when it can be sometimes positive and sometimes negative as the Feynman parameters and external momenta change.
How should I do? Thank you.
Something new should be posted here.

A little bit ugly, but you can see it clearly.
The exact integral that I am fighting is the following: $$ \int d^4 k \cdot EXP \frac {TR}{[k^2-m_4^2][(k+p_1)^2-m_1^2][(k+p_2+p_3)^2-m_2^2][(k+p_3)^2-m_3^2]}, $$ where $EXP$ stands for 3 exponential functions, which come from the 3 effective meson vertices, whose effect is to depress the UV part of the integral to make it finite. However they are fairly complicated, look like the following, $ EXP=\exp[\frac{k^2 p_1^2-(k\cdot p_1)^2}{c_1^2}]\cdot\exp[\frac{[k^2 p_2^2-(k\cdot p_2)^2]+[p_2^2p_3^2-(p_2\cdot p_3)^2]+[2k \cdot p_3 p_2^2 - 2k\cdot p_2 p_2\cdot p_3]}{c_2^2}]\cdot\exp[\frac{k^2 p_3^2-(k\cdot p_3)^2}{c_3^2}], $ $ TR=tr[\gamma^5(m_4+ k\!\!\!/)\gamma^5(m_3+ k\!\!\!/ + p\!\!\!/_3)\gamma^5(m_2+ k\!\!\!/ +p\!\!\!/_2+ p\!\!\!/_3)\gamma^{\mu}(1-\gamma^5)(m_1+k\!\!\!/+p\!\!\!/_1)] $
Numerical methods may be needed to get the value of the integral. Maybe I can try another easier meson vertices, which look like this, $EXP=\exp(c k^2)$, which seem that a analytic method can be applied. However I have tried several analytic methods, I failed all of them.
I will post the method that I want to carry out. Using Feynman parameterization + residue theorem.
Write the integral above as the following: $$ \int d^4 k \frac{f^{\mu}(k)}{[k^2-m_4^2][(k+p_1)^2-m_1^2][(k+p_2+p_3)^2-m_2^2][(k+p_3)^2-m_3^2]}\\ =3!\cdot \int d^4 k \int _0 ^1 dx_1 dx_2 dx_3 dx_4 \delta(\sum x_i -1) \frac{f^{\mu}(k)}{[(k+P)^2-\Delta]^4}\\ =3!\cdot \int d^3 k d k^0 \int _0 ^1 dx_1 dx_2 dx_3 dx_4 \delta(\sum x_i -1) \frac{f^{\mu}(k)}{[(k^0+P^0)^2-(\textbf{k}+\textbf{P})^2-\Delta]^4} $$
(where $f(k)=EXP \cdot TR$, which is very complicated, and which makes this integral so muddy.)
if $(\textbf{k}+\textbf{P})^2+\Delta < 0$, then close the contour above(for example) to enclose a pure imaginary root in it, then use residue theorem.
if $(\textbf{k}+\textbf{P})^2+\Delta \geq 0$, then close the contour above(for example) to enclose a root which looks like $a + i\epsilon$ in it, then use residue theorem.
There are several words to say.
1) Clearly I have to use ugly numerical method.
2) My tutors worry about the situation near 0, that is when $(\textbf{k}+\textbf{P})^2+\Delta$ is close to 0, what will happen?
3) Using residue theorem requires to differentiate a very very complicated function for the third order derivative, which is hard to realize it.
If this method is right, I will try it although it is hard to carry out.
I want to hear some confirmation or some criticism. Thank you.