To emphasize the connection between the main formula and the three explanatory lines, I'd place them all in an align* environment. No real need to clutter up the picture with text bullets.

\documentclass{article}
\usepackage{mathtools}
\DeclareMathOperator{\E}{E} % define the expectation operator symbol
\begin{document}
\begin{align*}
\E[g(x)] &= \int_{-\infty}^{+\infty} f_X(x) g(x) \, \mathrm{d}x\\
\shortintertext{where}
x &\ \text{is a continuous random variable,}\\
f_X(x) &\ \text{is the pdf of $x$, and}\\
g(x) &\ \text{is a function of $x$.}
\end{align*}
\end{document}
If more space is desired between the variables and the explanatory text, one could replace &\ with &\quad.
Second proposed solution, incorporating information that this is part of a beamer document:

\documentclass{beamer}
\usepackage{amsmath}
\DeclareMathOperator{\E}{E}
\begin{document}
\begin{frame}
$\begin{array}{l@{}l}
\E[g(x)]&{}= \int_{-\infty}^{+\infty} f_X(x) g(x)\, \textnormal{d}x, \text{ where}\\[0.75ex]
x &\text{is a continuous random variable,}\\
f_X(x) &\text{is the pdf of $x$, and}\\
g(x) &\text{is a function of $x$.}
\end{array}$
\end{frame}
\end{document}
Observe that because the main text font is not a "roman"/serif font, it's better to use \mathnormal than \mathrm to set the "differential operator" symbol d in upright shape.
usepackage{enumitem}and\begin{itemize}[align=left]and then\item[$x$]{is a continuous random variable.}? – Adam Liter Nov 30 '13 at 08:59